Map - Guilford County, North Carolina (Guilford County)

Guilford County is a county located in the U.S. state of North Carolina. As of the 2020 census, the population is 541,299, making it the third-most populous county in North Carolina. The county seat, and largest municipality, is Greensboro. Since 1938, an additional county court has been located in High Point. The county was formed in 1771. Guilford County is included in the Greensboro-High Point, NC Metropolitan Statistical Area, which is also included in the Greensboro-Winston-Salem-High Point, NC Combined Statistical Area.

At the time of European encounter, the inhabitants of the area that became Guilford County were a Siouan-speaking people called the Cheraw. Beginning in the 1740s, settlers arrived in the region in search of fertile and affordable land. These first settlers included American Quakers from Pennsylvania, Maryland, and New England at what is now Greensboro, as well as German Reformed and Lutherans in the east, British Quakers in the south and west, and Scotch-Irish Presbyterians in the center of today's Guilford County. As population increased, the North Carolina colonial legislature organized the county in 1771, from parts of Rowan and Orange counties. It was named for Francis North, Earl of Guilford, father of Frederick North, Lord North, British Prime Minister from 1770 to 1782.

Friedens Church, whose name means "peace" in German, is in eastern Guilford County, at 6001 NC Hwy 61 North, northwest of Gibsonville. It is a historic church established by some of the earliest European settlers in this area. According to a church history, Rev. John Ulrich Giesendanner led his Lutheran congregation from Pennsylvania in 1740 into the part of North Carolina around Haw River, Reedy Fork, Eno River, Alamance Creek, Travis Creek, Beaver Creek, and Deep River. Friedens Church built a log structure in 1745, which the congregation used for 25 years. The second building, completed about 1771, was more substantial and was used for a century, being replaced in May 1871. That third building was destroyed by fire on January 8, 1939, with only the front columns surviving destruction. The church was rebuilt and reopened in May 1939.

The Quaker meeting also played a major role in the European settlement of the county. Numerous Quakers still live in the county. New Garden Friends Meeting, established in 1754 and first affiliated with a Pennsylvania meeting, still operates in Greensboro.

Alamance Presbyterian Church, a log structure, was built in 1762. The congregation was not officially organized until 1764 by the Rev. Henry Patillo, pastor of Hawfields Presbyterian Church. It has operated since then on the same site in present-day Greensboro. According to the church history, the congregation has built five churches on that site and now has its eighteenth pastor.

On March 15, 1781, during the American Revolution (1775-1783), for independence from Great Britain, the Battle of Guilford Court House was fought just north of present-day Greensboro between Generals Charles Cornwallis and Nathanael Greene. This battle marked a turning point in the Revolutionary War in the South. Although General Cornwallis, the British commander, held the field at the end of the battle, his losses were so severe that he decided to withdraw to the Carolina coastline, where he could receive reinforcements from the British Royal Navy at the port in Wilmington and his battered army could be protected by the British naval power. His decision ultimately led to his leading his finished ravaged army north into Virginia leading eventually to his defeat and surrender later in October 1781 at Yorktown, Virginia after a long siege, by a combined force of American and French Royal troops and blockading French Navy warships on the Chesapeake Bay.

In 1779, the southern third of Guilford County was separated and erected as Randolph County. In 1785, following the American Revolution, the northern half of its remaining territory was organized as Rockingham County.

In 1808, the town of Greensboro replaced the hamlet of Guilford Court House as the county seat. It was more centrally located, making it a better location for travelers of the time.

The county was the site of early industrial development, namely, the Mt. Hecla Cotton Mill, established in 1818 as one of the earliest cotton mills in the state. First run by water power, the mill was refitted to be powered by steam, and was one of the earliest examples in the state of the use of steam power for manufacturing.

In the antebellum era, many of the county's residents were opposed to slavery, including Lutherans, Quakers and Methodists. The county was a stop on the Underground Railroad, for which volunteers aided refugee slaves en route to freedom in the North. People gave them safe places to stay and often food and clothing. Levi Coffin, among the founders of the "railroad," was a Guilford County native. He is credited with personally helping more than 2,000 slaves escape to freedom before the war.